As Twitter Bootstrap still lacks out of the box RTL support to its frameworks, we still need to do the extra step and RTL the framework. Now with tools like RTLCSS, it's becoming easier and faster to add the RTL support to the framework. Not only did they do that, but also they're offering a CDN where you can directly link and use the RTLed version.
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Adding RTL support to a drupal theme can be time consuming. Also maintaining it is not easy. I've figured out a way to have a bidirectional drupal theme, by using the power of CSS preprocessors and the amazing framework "Foundation".
FlexSlider is an awesome, fully responsive and almost perfect jQuery slider plugin. Unfortunately it lacks RTL support. The good news is that it required few CSS and JS modifications to add the RTL support to it.
UPDATE: The latest version of Book Block now supports RTL. No need to use my version anymore. Get it from codrops/BookBlock
UPDATE: Check Bootstrap with RTL Support for v3.3.7